MASON, Ohio -- Andy Murray followed up his second Olympic singles title with a second-round victory on Wednesday night in the Western & Southern Open.The top-seeded Scot beat Argentinas Juan Monaco 6-3, 6-2 to set up a match against South Africas Kevin Anderson, a 6-2, 6-4 winner over 13th-seeded Richard Gasquet of France.Murray had trouble adjusting to the balls and called for a trainer to attend to his right shoulder in the first set. He won nine of the final 11 games.Theres different balls here, and thats something thats not easy for a tennis player, and you have to be careful with that, Murray said. It totally changes how it feels on the racket and how it feels through your body, as well. I served better in the second set. Its just at the start, it was a bit sore. Ive played a lot of tennis, but its also the ball change.On Sunday in Rio, Murray beat Argentinas Juan Martin del Potro in four sets in the final.Murray won the hard-court event in 2008 and 2011 and has reached the quarterfinals in eight of his previous 11 appearances in Cincinnati.Earlier, Rafael Nadal defeated Uruguays Pablo Cuevas 6-1, 7-6 (4).Nadal, the third-seeded Spanish star who won the tournament in 2013, also was coming off the Olympics, where he teamed with Marc Lopez to win the doubles title and lost in the bronze-medal singles match. Before that, the 30-year-old Nadal had missed two months with an injured left wrist.I think I played well, Nadal said. I think I played a good match against a tough opponent in the first round for me for sure. After coming from Rio and after the marathon that I had, its a very important victory for me. So Im very happy.Nadal avenged a loss to Cuevas in February in Rio de Janeiro in a clay-court event to set up a third-round match against Croatias Borna Coric, a 7-6 (2), 4-6, 7-6 (6) winner over 14th-seeded Nick Kyrgios of Australia.Second-seeded Stan Wawrinka of Switzerland also advanced, beating American Jared Donaldson 2-6, 6-3, 6-4.Also, fourth-seeded Milos Raonic of Canada outlasted American John Isner 7-6 (5), 7-6 (5); fifth-seeded Kei Nishikori?of Japan topped Russias Mikhail Youzhny 6-3, 6-2; sixth-seeded Tomas Berdych of the Czech Republic beat Spains Marcel Granollers 6-3, 7-6 (4); and seventh-seeded Jo-Wilfried Tsonga of France edged American Reilly Opelka 7-6 (5), 7-6 (3).Defending champion Roger Federer and top-ranked Novak Djokovic are sidelined by injuries.In womens second-round play, second-seeded Angelique Kerber of Germany beat Frances Kristina Mladenovic 6-0, 7-5; third-seeded Simona Halep of Romania edged Germanys Annika Beck 6-3, 6-1; and fourth-seeded Garbine Muguruza of Spain topped American Coco Vandeweghe 7-6 (4), 6-2.With two-time defending champion Serena Williams forced to withdraw because of an inflamed shoulder, Kerber is in position to take the top spot in the rankings with a tournament victory. Williams has been in the top spot for 183 consecutive weeks.Its not on my mind, Kerber said. If the time is ready and I can reach the No. 1, of course,it will be amazing. Still, its for me still a long, long way to get there.Halep has won 11 straight matches and her last two tournaments at Bucharest and Montreal.I feel confident. I had pretty good tournaments before coming here, and I feel my game, Halep said. I was a little bit nervous before the match, because I had two weeks after without matches. Like everyone says, its tough, the first match of the tournament. Now Im more relaxed and Im looking already forward to the next one.Rain delayed the start of play for 90 minutes. The tournament had 39 singles matches scheduled for Wednesday, making up for weather delays over the first two full days of play. There were eight matches either suspended or postponed from Tuesday that were completed on Wednesday. All eight winners played second matches in the evening. 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CHICAGO -- Ashton Millender scored 19 points, Amarah Coleman had 16, and No. 21 DePaul raced to a 45-point halftime lead en route to a 99-58 season-opening win over Appalachian State on Friday night.DePaul led 30-5 after the first quarter, forcing the Mountaineers into 14 turnovers in that span and 20 in the first 15 minutes. For the game, the Blue Demons converted 32 turnovers into 35 points.Brooke Schulte scored six straight in the second quarter as part of a 14-0 rrun to boost DePauls lead to 47-9.dddddddddddd Schulte finished with 10 points, one of five Demons in double figures. Deja Cage had 13 points and Jessica January 14 to go with seven assists and five steals.DePaul led by as many as 51 points by the middle of the third quarter.Q. Murray and Madi Story each had 11 points for Appalachian State. ' ' '